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Cosmetics

Cosmetics

exo PARTiCLE® exo PARTiCLE®

exo PARTiCLE®

This is the birth of cosmetics that are very rare in the world.
They are full of small particles containing plant-derived exosomes and uniform 5Nano 24K.

Cosmetics

The latest research on exosomes in the field of regenerative medicine
Cosmetics developed with advanced technology from nanoparticles contained in exosomes
This is exo PARTiCLE®
We, ASFREYA, have succeeded in making 24K gold into a uniform 5Nano using our unique technology.
Exosomes in rice fermentation extract can be expected to have a whitening effect, and by adding 24K gold to exosomes, it can be expected to increase collagen production. This is the birth of the next generation of aging cosmetics.

exo PARTiCLE
exo PARTiCLE

Skin cells are constantly reborn as new cells, but restoring damaged skin means suppressing various inflammations and repairing tissues.
Exosomes released from cells have the function of transmitting information as a messenger and returning to the original healthy skin condition.
We focused on the breakthrough function of exosomes in the development of exo PARTiCLE®

Exosome

Exosomes contained in exo PARTiCLE®
Let's break down the characteristics of exosomes into two points.

the characteristics of exosomes into two points
Exosomes of rice fermentation extract

Exosomes of rice fermentation extract
The Key to Beauty Solutions

The rice fermented liquid is made by fermenting brown rice with a special koji (rice malt) mold. In addition to the ingredients of brown rice, the rice fermented liquid also contains active ingredients such as amino acids and kojic acid by fermenting malted rice.
Fermented liquid made by fermenting malted rice is so nutritious that it is called "drinkable intravenous drip" or "drinkable beauty essence".
Also, the particle shape of rice fermentation is around 100 nanometers, centered on 85 nanometers. The particles are likely to be uniformly taken up by cells and are numerous. The number of particles of rice fermentation extract used in exo PARTiCLE® is about 236 million per ml, which not only promotes the production of collagen and elastin but can also be expected to have a whitening effect.

Skin regeneration ability of rice fermentation extract

Skin regeneration with rice fermentation extract has long been well known. Since the effect may be exerted by exosomes, the effect of exosome particles of rice fermented liquid on human fibroblasts was examined from the viewpoint of inducing the expression of Type I collagen and Elastin genes.

Skin regeneration ability of rice fermented liquid exosomes: Result Skin regeneration ability of rice fermented liquid exosomes: Result
Skin regeneration ability of rice fermented liquid exosomes: Result Skin regeneration ability of rice fermented liquid exosomes: Result
Skin regeneration ability of rice fermented liquid exosomes: Result

Focusing on the Beauty Benefits of Gold.

Focusing on the Beauty Benefits of Gold.

Pure 24K gold is successfully nanosized using the latest technology.
It is homogenized to 5 nanometers for quick penetration into the skin.
The uniformly decomposed gold promotes the activation of cells and increases the penetrating power to activate the skin. This is the approach prescription that enhances the immunity.
"24 gold" which is said to have been used by Cleopatra for beauty.
Gold activates the skin's immunity and produces hyaluronic acid, collagen, and elastin.
Negative ions from gold activate skin turnover and bring about beauty benefits such as "antiwrinkle effect", "anti-inflammatory effect" and "suppression of melanin production".
In addition, due to its high stability, it can be expected to have an excellent antioxidant effect that is less susceptible to oxidation.

Electron micrograph of 24K uniform 5 nanosized particles

The distance between skin cells is about 50 nanometers.
Also, the space between cells is not blank, but filled with body fluids.
We, ASFREYA, have succeeded in uniforming 24K pure gold to 5 nanometers with the latest nanotechnology in cooperation with nanotechnology research and development at Kyoto University.
The 5 nanoparticles of gold is small in size, and the gravity is the same as buoyancy. Then, even if the particles enter into the skin, they are immediately taken out of the skin by effect of expelling foreign substances. The particles are safe because they do not penetrate deeper than the basal layer.
The gold is uniformly decomposed into 5 nanometers that quickly penetrates the skin. It promotes cell activation and enhances firmness and gloss with a positive approach to wrinkles and sagging due to aging.

Melanin synthesis inhibitory effect of AA-2G

Experimental method:
1) B16 melanoma cells were cultured for 12 hours in the presence or absence of AA-2G (2.5 mM), and then theophyline (0.5 mM) was added.
2) After 48 hours, the cells were reacted with L-dopa for 1.5 hours, and nuclear staining was performed with nuclear fast red.
[Miyai and Yamamoto et al., Nishinihon J.Dermotol.,58(3),439(1996)]

Additive-free (control) AAA-2G added (2.5mM)